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KMID : 0923620140140050260
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Immune Network
2014 Volume.14 No. 5 p.260 ~ p.264
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Immunomodulatory Effects of ZYM-201 on LPS-stimulated B Cells
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Lee Ye-Eun
Kim Soo-Chan
Jung Woong-Jae
Lee Hyung-Soo
Kim Mi-Yeon
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Abstract
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ZYM-201 is a methyl ester of triterpenoid glycoside from Sanguisorba officinalis which has been used for treatment of inflammatory and metabolic diseases. In this study, im-munomodulatory effects of ZYM-201 on B cells were exam-ined in vitro and in vivo. When splenocytes were activated with lipopolysaccharide (LPS), the major population which had shown an increase in cell numbers was B cells. However, when the B cells were treated with ZYM-201 after LPS acti-vation, their cell numbers and the expression of major cos-timulatory molecules, CD80 and CD86, were decreased. Furthermore, the effect of LPS, which induces activation of NF-?B, was abolished by ZYM-201: LPS-stimulated B cells showed decrease of phosphorylation after treatment of ZYM-201. The same results were shown in vivo experiments. These results suggest that ZYM-201 may play a role in the modulation of inflammatory responses through inhibiting NF-?B activation and downregulating the expression of cos-timulatory molecules on B cells.
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KEYWORD
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ZYM-201, B cell, Inflammation, LPS
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